Publications

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Jan 1970

Efficacy of a Novel Local Prolonged-Release Incisional Doxycycline on Surgical Site Infection Prophylaxis in Abdominal Colorectal Surgery: The SHIELD II Phase 3 Randomized Clinical Trial

2025 American College of Surgeons (ACS) Clinical Congress

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Oct 2024

Effect of local prolonged-release incisional doxycycline on surgical site infection prophylaxis in abdominal colorectal surgery: the SHIELD 1 randomized clinical trial

International Journal of Surgery

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Oct 2023

Impact of Locally Applied Doxycycline-Eluting Drug (D-PLEX) on Incisional Infection Rate in Elective Colorectal Surgery: A Phase 3, Prospective, Randomized, Double-Blind, Multicenter and Multinational Clinical Trial

American College of Surgeons Clinical Conference 2023

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Oct 2023

Preclinical In-Vivo Safety and Toxicokinetics of D-PLEX100 in an Abdominal Surgery Incision Model in Juvenile Miniature Swine

International Journal of Toxicology

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Jul 2023

Potent antibacterial activity in surgical wounds with local administration of D-PLEX100

European Journal of Pharmaceutical Sciences

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Nov 2022

Reduction in surgical site infections by localized administration with D-PLEX100 in patients with multiple risk factors undergoing colorectal surgery

The American Journal of Surgery

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Sep 2022

D-PLEX, a doxycycline releasing antimicrobial product for surgical site wounds, reduces surgical site infection rates and drug resistant-bacteria in surgical trauma injuries

The 2022 Military Health System Research Symposium (MHSRS)

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Sep 2022

D-PLEX100, a novel doxycycline formulation that provides high, local concentrations of antibiotic activity for 30 days to reduce surgical site infections

The European Society of Coloproctology (ESCP) 2022 Annual Meeting

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Sep 2022

A prospective, randomized assessment of a novel, local antibiotic releasing platform for the prevention of superficial and deep surgical site infections

Techniques in Coloproctology

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Aug 2022

Reduction in Surgical Site Infections by Localized Administration with D-PLEX100 in Patients with Multiple Risk Factors Undergoing Colorectal Surgery

MSA 2022 Annual Meeting

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Technology

PolyPid’s PLEX targeted drug delivery platform enables localized, controlled, continuous release of medication over prolonged periods of time for better patient outcomes.

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D-PLEX100

Is designed to prevent the risk of surgical site infections in both bone and soft tissue through its cutting-edge, local, extended-release mechanism

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D-PLEX1000

Comprised of antibiotic eluting ß tri-calcium phosphate (ßTCP) granules, designed for bone related infections applications.

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