Publications

May 2022

From Bench to Bedside: D-PLEX limits AMR occurrence in randomized double-blind phase 2 trial in colorectal surgery patients

13th European and Global CLINAM-Summit

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Apr 2022

Incisional microenvironments and reduction in SSIs in patients treated with a local doxycycline-eluting formulation

Surgical Infection Society (SIS) - 41st Annual Meeting

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Mar 2022

D-PLEX100, a novel doxycycline formulation that provides high, local concentrations of antibiotic activity for approximately four weeks to reduce Surgical Site Infections

SAGES 2022 Annual Meeting - The Next Big Thing

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Dec 2020

Local prolonged release of antibiotic for prevention of sternal wound infections postcardiac surgery-A novel technology

Journal of Cardiac Surgery

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Jun 2020

D-PLEX100 in an Abdominal Surgery Incision Model in Miniature Swine: Safety Study

Toxicologic Pathology

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Jun 2020

D-PLEX500: A Local Biodegradable Prolonged Release Doxycycline-Formulated Bone Graft for the Treatment for Peri-Implantitis. A Randomized Controlled Clinical Study

Quintessence Int.

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May 2019

Toxicity and Safety Study of D-PLEX100 in a Sternal Surgical Defect in New Zealand White Rabbits

Toxicologic Pathology

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Jun 2017

Controlled Release of LL-37-Derived Synthetic Antimicrobial and Anti-Biofilm Peptides SAAP-145 and SAAP-276 Prevents Experimental Biomaterial-Associated Staphylococcus aureus Infection

Advanced Functional Materials

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Dec 2015

Prevention of Staphylococcus aureus biomaterial-associated infections using a polymer-lipid coating containing the antimicrobial peptide OP-145

Journal of Controlled Release

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Jul 2015

A doxycycline-loaded polymer-lipid encapsulation matrix coating for the prevention of implant-related osteomyelitis due to doxycycline-resistant methicillin-resistant Staphylococcus aureus

Journal of Controlled Release

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Technology

PolyPid’s PLEX targeted drug delivery platform enables localized, controlled, continuous release of medication over prolonged periods of time for better patient outcomes.

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D-PLEX100

Is designed to prevent the risk of surgical site infections in both bone and soft tissue through its cutting-edge, local, extended-release mechanism

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D-PLEX1000

Comprised of antibiotic eluting ß tri-calcium phosphate (ßTCP) granules, designed for bone related infections applications.

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