Jan 1970

Protected: Plex Platform Pipeline new

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Jan 1970

Protected: About D-PLEX100-New

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Jan 1970

CLINICAL TRIALS

CONSISTENT CLINICAL RESULTS DEMONSTRATED ACROSS TRIALS POLYPID'S PHASE 3 CLINICAL TRIALS: D-PLEX100 – 302 – (NCT03558984) –  Open heart surgery Efficacy and Safety of D-PLEX in the Prevention of Sternal Infection Post Cardiac Surgery. Phase III, Prospective, Multinational, Multicenter, Randomized, Parallel Controlled, Two arms, Single Blind, Study to Assess the Efficacy and Safety of D-PLEX Administered Concomitantly…

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Jan 1970

PREVENTION of SSIs

CHASING ZERO: THE DRIVE TO ELIMINATE SURGICAL SITE INFECTIONSSSIs remain a substantial cause of morbidity, prolonged hospitalization, and death. SSI are the second most common hospital acquired infections in United States and the European Union and occur in approximately 2% to 5% of patients undergoing inpatient surgery worldwide 1. The incidence of SSI is doubled…

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Jan 1970

Peri Implantitis

TREATMENT OF PERI-IMPLANTITIS - ONE OF THE MOST CHALLENGING Biofilm Metal Implant Chronic Infection Constant Contamination Mix Bacterial Makeup Primary efficacy endpoint: D-PLEX500 reduces Probe Pocket depth (PPD) vs. SoCD-PLEX500 prevented the loss of implants

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Jan 1970

SEVERE OPEN FRACTURES TREATMENT

Another product candidate from the PLEX-doxycycline family, for use in connection with orthopedic surgeries for the prevention of SSIs and support of bone recovery. [siteorigin_widget class="video_Widget"][/siteorigin_widget] D-PLEX1000 Showed Effective Treatment of Orthopedic Surgeries No deep bone infections after 6 months across 24 treated patients, in comparison with reported incidences in the literature ranging between 7%…

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Jan 1970

D-PLEX100 EFFICACY

D-PLEX100 – PHASE 2 - SIGNIFICANT DECREASE IN THE RATE OF SSI  IN ABDOMINAL SURGERIES Design: accessor and patient blinded and double-arm randomized study Objective: safety and efficacy of D-PLEX100 + SoC (n=101) vs. SoC alone (n=100) in prevention of incision infection post-colorectal surgery Primary efficacy end-point: the decrease of infection rate as measured by…

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Jan 1970

Ongoing Clinical Trials

PolyPid’s ongoing clinical trials: D-PLEX100 – 301 – (NCT02731573) - Completed Initial Safety and Efficacy of D-PLEX100 in the Prevention of Primary Sternal Infection Post Cardiac Surgery. For more information, please visit clinicaltrials.gov: https://clinicaltrials.gov/ct2/show/NCT02731573?term=D-PLEX&rank=1 D-PLEX100 – 302 – (NCT03558984) Efficacy and Safety of D-PLEX in the Prevention of Sternal Infection Post Cardiac Surgery For more information, please…

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Jan 1970

PLEX PLATFORM PIPELINE

  OUR PIPELINE IS DESIGNED TO ADDRESS DISEASES WITH HIGH UNMET MEDICAL NEEDS We paired our PLEX technology with drugs already approved by the U.S. FDA or innovative drug candidates   POLYPID'S PHASE 3 CLINICAL TRIALS: D-PLEX100 – 302 – (NCT03558984) –  Open heart surgeryEfficacy and Safety of D-PLEX in the Prevention of Sternal Infection Post…

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Jan 1970

About D-PLEX100

LOCALIZED DRUG DELIVERY SYSTEM STUDIED FOR PREVENTION OF SSIs Active Ingredient: Doxycycline (broad-spectrum antibiotic) Release Duration: Prolonged effect of 30 days Indication: prevention of post-cardiac surgery sternal infection and post abdominal surgery incisional infection Release profile: No burst, constant & linear release Dosing: Varies by incision size 1vial < 10cm, 10cm < 2vials > 20cm,…

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Technology

PolyPid’s PLEX targeted drug delivery platform enables localized, controlled, continuous release of medication over prolonged periods of time for better patient outcomes.

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D-PLEX100

Is designed to prevent the risk of surgical site infections in both bone and soft tissue through its cutting-edge, local, extended-release mechanism

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D-PLEX1000

Comprised of antibiotic eluting ß tri-calcium phosphate (ßTCP) granules, designed for bone related infections applications.

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