We are developing a family of product candidates for the management of SSIs consisting of PLEX paired with doxycycline, a widely-used, FDA-approved antibiotic, which we refer to as our PLEX-doxycycline family.

Our PLEX-doxycycline family of product candidates are secure antibiotic drug reservoirs that use our PLEX technology to physically encapsulate doxycycline and release it at the local target site at predetermined rates and durations, and are designed to provide localized and prolonged infection management after surgery. The PLEX matrix in this family consists of thousands of layers of polymers and lipids that are designed to mediate the release of doxycycline for up to four weeks.

The product candidates in this family are each based on the same specific PLEX formulation and are designed to be used with doxycycline.


Our product candidates are supplied as sterile powders and may be administered locally as a powder or paste during surgery to a variety of tissues and solid organs.


An antibiotic drug reservoir designed to be implanted during surgery to prevent or treat surgical site infections (SSIs)

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BONYPID - 1000™

An antibiotic eluting ß tri-calcium phosphate (ßTCP) granules, designed for bone related infections applications

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BONYPID - 500™

An antibiotic eluting bone graft substitute intended to fill, augment or reconstruct periodontal or oral/maxillofacial defects while protecting from infections

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Annual number of procedures in the US and Europe

  • Bone Surgeries

    Cardiac Surgeries, Orthopedic Surgeries


  • Soft Tissue Surgeries

    General Surgeries, Gynecological Surgeries, Urologic Surgeries



    Our internal pipeline includes PLEX-based products, which are designed to release antibiotics in a variety of medical conditions over extended periods of time.




    The PLEX™ (Polymer-Lipid Encapsulation matriX) platform is a matrix made of alternating layers of polymers and lipids that allows controlled, local release of unmodified drugs over extended periods of time.

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    Provides safe and effective local antibiotic protection against SSI (surgical Site Infection) at the needed tissues or organs by administration during surgical procedures.

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    Comprised of antibiotic eluting ß tri-calcium phosphate (ßTCP) granules, designed for bone related infections applications.

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